fenbendazole for humans is a widely used benzimidazole anthelmintic drug with anticancer activities. These activities include stabilization of WT p53, moderate microtubule disruption, and interference with cancer cells’ glucose metabolism.
These effects may overlap with the mechanisms of action of hypoxia-selective nitroheterocyclic cytotoxins/radiosensitizers and taxanes. We examined the effectiveness of fenbendazole in combination regimens.
Safety
Fenbendazole is a broad-spectrum antiparasitic drug that is effective against several species of parasitic worm, including some tapeworms. It also has a number of antifungal activities and is used to treat intestinal helminth infections in animals, including Giardia and nematodes. It is often prescribed for cats, as it is an effective treatment for their intestinal helminths and lungworms. It is also very effective against pulmonary helminths in dogs, such as Ancylostoma and Trichuris. The benzimidazole is very safe for mammals and does not interact with other medications. Moreover, the dosage required to control cryptococcosis is considerably lower when combined with fenbendazole than with standard lipid formulations of amphotericin B. In addition, fenbendazole has been shown to have many anticryptococcal effects and does not have significant toxicity to mammalian cells. These properties make it a promising candidate for future development of a human fenbendazole derivative that could be an alternative to amphotericin B.
A case report of a patient with advanced non-small cell lung cancer who was taking fenbendazole off-label to treat her gastrointestinal symptoms associated with her tumor was published. The patient received information on fenbendazole through social media, which led her to purchase the medication and orally self-administer it. The patient experienced a reduction in her gastrointestinal symptoms, but she did not experience tumor shrinkage. It is important for physicians to enquire about patients’ use of social media to ensure they are getting accurate medical information.
Efficacy
Fenbendazole is an antiparasitic drug used to treat parasitic worms and parasites in animals such as dogs. Researchers from Panjab University, India, have recently found that this veterinary medication may also be effective against cancer. They published their findings in the journal Scientific Reports.
This treatment method is also known as the Joe Tippens Protocol, named after a terminal cancer patient who claimed that the treatment had led to remission. Although some research has shown that fenbendazole can suppress cancer cells in petri dishes and mice, there isn’t enough evidence to show that it works in humans. There is no evidence that fenbendazole cures cancer, and it certainly wouldn’t prevent recurrent tumors from returning after surgery or other established treatments.
Fenbendazole works by inhibiting the growth of microtubules, which provide structure to cells. It does so by disrupting the polymers that make up the tubulin proteins, which are part of the cytoskeleton. This protein scaffold is essential for cellular movement, transporting organelles and cargo, and maintaining cell shape.
The researchers found that fenbendazole was effective against Cryptococcus neoformans and C. gattii at low concentrations and did not cause adverse effects in normal human cells. Additionally, it promoted the effectiveness of amphotericin B, an antifungal drug. The authors also noted that the benzimidazole antihelminthics have little toxicity in mammals, which makes them an ideal candidate for repositioning as human anti-cancer agents.
Dosage
Fenbendazole is a common medication used to treat parasites and worms in animals. It is also being used in a cancer treatment protocol that has been popularized on TikTok and other social media platforms by Joe Tippens, a US man who claims to have cured his cancer with fenbendazole and other supplements. Although some studies have shown that fenbendazole can slow the growth of cancer cells in cell cultures and mice, it is not clear whether this effect is applicable to humans.
The benzimidazole carbamate drug works by inhibiting microtubule polymerization and glucose uptake in cancer cells, which reduces glycogen stores and ATP production. It is believed that fenbendazole may also help evade the development of resistance to chemotherapy drugs. It is also able to target multiple pathways, unlike single-target drugs that can easily become resistant.
Although there are a number of reports of people using fenbendazole to cure their cancer, most of these claims are anecdotal and have not been verified by scientific research. Experts say that there is no evidence that the drug can cure cancer in humans, and more clinical trials are needed before it can be considered safe and effective. A specialist cancer information nurse at Cancer Research UK told Full Fact that there is insufficient evidence that fenbendazole is an effective cancer treatment.
Side effects
Fenbendazole is a widely used anthelmintic drug that’s been shown to be effective against parasites in animals. It’s also been shown to be able to slow down cancer cells in petri dishes and mice. But it hasn’t been tested in people, and there’s no evidence that it can cure cancer.
Some research suggests that fenbendazole might be able to suppress cancer cell growth by interfering with microtubules. These are structures that bind to chromosomes and are crucial for cell division. They help to line up chromosomes for separation during anaphase, and separate them evenly during metaphase. Cancer cells have disrupted microtubules, which may be why they grow faster than normal cells.
A Facebook post by a Joe Tippens supporter claims that the anthelmintic fenbendazole can kill cancer cells “unlike your NHS shit that just make them lay dormant/sleep until they are ready to wake back up”. The post links to the Joe Tippens protocol, which consists of fenbendazole, vitamins and supplements.
However, Full Fact has consulted an expert in cancer information, and they say that there’s no evidence that the Joe Tippens protocol works. In fact, there’s no evidence that fenbendazole has any anticancer effects at all.
The post also implies that fenbendazole doesn’t cause side effects, but it’s important to remember that this medication is usually prescribed by a veterinarian. It’s important to follow the storage instructions for fenbendazole, as it can be dangerous if it’s not stored properly.